While the title may be bold there is a possibility that there is one game that could take the Xbox One and change it forever in regard to turning it against DRM and the always on function. The game that we are talking about is Crackdown 3.
So why would the team working on the Xbox One disregard such a game? Well one explanation could be that people get used to certain things and often take them for granted. This could be the reason and the person behind it could realise this.
Crackdown would bring with it a physical game and the game does have compute power along with memory on demand and this means it could be just as destructible as people want it to be. The Cloud engine and Microsoft Azure collaboration would mean it had 13 times the physics computing power that the Xbox One would put in reserve for data and this would make it a complete makeover.